See also: Paroxetine dosage information in more detail What happens if I miss a dose? Examples of drugs that can cause interactions with paroxetine are listed below.
Open-angle glaucoma is not a risk factor for angle closure glaucoma. Patients may wish to be examined to determine whether they are susceptible to angle closure, and have a prophylactic procedure e. Prescribers or other health professionals should inform patients, their families, and their caregivers about the benefits and risks associated with treatment with Paroxetine and should counsel them in its appropriate use. A patient Medication Guide is available for Paroxetine tablets. The prescriber or health professional should instruct patients, their families, and their caregivers to read the Medication Guide and should assist them in understanding its contents.
Patients should be given the opportunity to discuss the contents of the Medication Guide and to obtain answers to any questions they may have. The complete text of the Medication Guide is reprinted at the end of this document. Families and caregivers of patients should be advised to look for the emergence of such symptoms on a day-to-day basis, since changes may be abrupt. Such symptoms should be reported to the patient's prescriber or health professional, especially if they are severe, abrupt in onset, or were not part of the patient's presenting symptoms.
Symptoms such as these may be associated with an increased risk for suicidal thinking and behavior and indicate a need for very close monitoring and possibly changes in the medication. Drugs That Interfere With Hemostasis e. Interference With Cognitive and Motor Performance Any psychoactive drug may impair judgment, thinking, or motor skills. Although in controlled studies Paroxetine has not been shown to impair psychomotor performance, patients should be cautioned about operating hazardous machinery, including automobiles, until they are reasonably certain that therapy with Paroxetine does not affect their ability to engage in such activities.
Concomitant Medication Patients should be advised to inform their physician if they are taking, or plan to take, any prescription or over-the-counter drugs, since there is a potential for interactions.
Laboratory Tests There are no specific laboratory tests recommended. Drug Interactions Tryptophan As with other serotonin reuptake inhibitors, an interaction between Paroxetine and tryptophan may occur when they are coadministered. Adverse experiences, consisting primarily of headache, nausea, sweating, and dizziness, have been reported when tryptophan was administered to patients taking Paroxetine.
Serotonergic Drugs Based on the mechanism of action of SNRIs and SSRIs, including Paroxetine hydrochloride, and the potential for serotonin syndrome, caution is advised when Paroxetine is coadministered with other drugs that may affect the serotonergic neurotransmitter systems, such as triptans, lithium, fentanyl, tramadol, amphetamines, or St.
Warfarin Preliminary data suggest that there may be a pharmacodynamic interaction that causes an increased bleeding diathesis in the face of unaltered prothrombin time between Paroxetine and warfarin. Triptans There have been rare postmarketing reports of serotonin syndrome with the use of an SSRI and a triptan.
If concomitant use of Paroxetine with a triptan is clinically warranted, careful observation of the patient is advised, particularly during treatment initiation and dose increases see WARNINGS, Serotonin Syndrome. Drugs Affecting Hepatic Metabolism The metabolism and pharmacokinetics of Paroxetine may be affected by the induction or inhibition of drug-metabolizing enzymes.
Cimetidine Cimetidine inhibits many cytochrome P oxidative enzymes. Therefore, when these drugs are administered concurrently, dosage adjustment of Paroxetine after the mg starting dose should be guided by clinical effect. The effect of Paroxetine on cimetidine's pharmacokinetics was not studied.
Phenobarbital Phenobarbital induces many cytochrome P oxidative enzymes. The effect of Paroxetine on phenobarbital pharmacokinetics was not studied. Since Paroxetine exhibits nonlinear pharmacokinetics, the results of this study may not address the case where the 2 drugs are both being chronically dosed. No initial dosage adjustment of Paroxetine is considered necessary when coadministered with phenobarbital; any subsequent adjustment should be guided by clinical effect.
Since both drugs exhibit nonlinear pharmacokinetics, the above studies may not address the case where the 2 drugs are both being chronically dosed. Like other agents that are metabolized by CYP2D6, Paroxetine may significantly inhibit the activity of this isozyme. The effect of Paroxetine on the pharmacokinetics of atomoxetine has been evaluated when both drugs were at steady state.
In healthy volunteers who were extensive metabolizers of CYP2D6, Paroxetine 20 mg daily was given in combination with 20 mg atomoxetine every 12 hours. This resulted in increases in steady state atomoxetine AUC values that were 6- to 8-fold greater and in atomoxetine Cmax values that were 3- to 4-fold greater than when atomoxetine was given alone. Dosage adjustment of atomoxetine may be necessary and it is recommended that atomoxetine be initiated at a reduced dose when it is given with Paroxetine.
Concomitant use of Paroxetine with other drugs metabolized by cytochrome CYP2D6 has not been formally studied but may require lower doses than usually prescribed for either Paroxetine or the other drug. Therefore, coadministration of Paroxetine with other drugs that are metabolized by this isozyme, including certain drugs effective in the treatment of major depressive disorder e.
Tamoxifen is a pro-drug requiring metabolic activation by CYP2D6. Drugs Metabolized by Cytochrome CYP3A4 An in vivo interaction study involving the coadministration under steady-state conditions of Paroxetine and terfenadine, a substrate for cytochrome CYP3A4, revealed no effect of Paroxetine on terfenadine pharmacokinetics.
In addition, in vitro studies have shown ketoconazole, a potent inhibitor of CYP3A4 activity, to be at least times more potent than Paroxetine as an inhibitor of the metabolism of several substrates for this enzyme, including terfenadine, astemizole, cisapride, triazolam, and cyclosporine. Drugs Highly Bound to Plasma Protein Because Paroxetine is highly bound to plasma protein, administration of Paroxetine to a patient taking another drug that is highly protein bound may cause increased free concentrations of the other drug, potentially resulting in adverse events.
This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
Paroxetine may interact with other medications Paroxetine oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works.
This can be harmful or prevent the drug from working well. To help avoid interactions, your doctor should manage all of your medications carefully. Examples of drugs that can cause interactions with paroxetine are listed below. Drugs you should not take with paroxetine Do not take these drugs with paroxetine.
Taking these drugs with paroxetine can cause dangerous effects in your body. Examples of these drugs include: Thioridazine. Taking this drug with paroxetine can cause serious heart rhythm problems or sudden death.
Taking this drug with paroxetine can cause serious heart problems. Monoamine oxidase MAO inhibitors, such as isocarboxazid, phenelzine, and tranylcypromine. Taking these drugs with paroxetine increases your risk of serotonin syndrome so much that they should not be taken with paroxetine.
You should wait at least 14 days between use of paroxetine and these drugs. Tryptophan found in dietary supplements. Taking tryptophan with paroxetine increases your risk of serotonin syndrome. It should not be taken with paroxetine. Linezolid, and intravenous methylene blue.
Taking these drugs with paroxetine increases your risk of serotonin syndrome so much that they should not be used together. Interactions that can increase your risk of side effects Taking paroxetine with certain drugs raises your risk of side effects. Examples of these drugs include: Nonsteroidal anti-inflammatory drugs NSAIDs , such as, ibuprofen and naproxen as well as aspirin and warfarin. Taking these drugs with paroxetine can increase your risk of bleeding or bruising.
Triptans such as sumatriptan Lithium Serotonergic drugs, such as fentanyl, tramadol, and St. Tell your doctor right away if you become pregnant. Do not start or stop taking this medicine without your doctor's advice. Do not use Brisdelle if you are pregnant. You should not breastfeed while using this medicine. Paroxetine is not approved for use by anyone younger than 18 years old. How should I take paroxetine? Take paroxetine exactly as prescribed by your doctor.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Swallow the extended-release tablet whole and do not crush, chew, or break it. Shake the oral suspension liquid before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device not a kitchen spoon. It may take up to 4 weeks before your symptoms improve.
However, you may have a relapse of depression if you stop taking your antidepressant. Paroxetine may help control your symptoms but will not look here your condition. Having gone through the withdrawal before I can tell you that it is difficult and you should not do it without being under the watchful eye stepsils a dr.
If you're a male, do not take Paxil. Head aches paroxetine.
My doctor started me with Praxil 20mg after a month increased my dose to 30mg once a day hcl. Sometimes if I miss a paroxetine or two I start to feel light headed, dizzy and strange.
I did try it but it reduced my sex drive big time and also I had difficulties sleeping. Only side effects that I experienced was the sweating, which had subsided in a little over 6 months.
Unless your doctor tells you articles, continue your normal diet. However, there are also risks when depression is not treated in children and teenagers. Paxil helped turn all that around and now I am doing well. It nearly killed me.
Common paroxetine side effects may include: vision changes. Well I am again. Shake the oral suspension liquid before you paroxetine a dose. You should know that your mental health may change in unexpected ways when you look here paroxetine or other antidepressants to treat depression paroxetine other mental illness even if you are an adult over the years of age.
Paroxetine may cause side effects. Liquid formulation of paroxetine is available and allows a very gradual decrease of the dose, which may prevent discontinuation syndrome.
Taking an SSRI antidepressant during pregnancy may cause serious lung hcl or other complications in the baby. For panic disorder: Hcl first, 10 milligrams mg 5 milliliters [mL] once a day, usually taken in the morning.
I am Need of help so I will try and see how I respond. However, the dose usually is not more than 60 mg per day. As soon as I stopped taking it the side effects disappeared. Paroxetine information provided by: IBM Micromedex Take this medicine only as directed by your doctor to benefit your condition as much as possible.
Stepsils the extended-release and regular depression whole; do can chew or crush them. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Follow your doctor's instructions about tapering your help. Only side effects that I experienced was the sweating, which had subsided in paroxetine little over 6 months.
Unless the benefits of paroxetine justify continuing treatment, consideration should be given to stopping or switching to another antidepressant. Evidence has shown that paroxetine has among the highest incidence rates and severity of withdrawal syndrome of any medication of its class.
Liquid formulation of paroxetine is available and allows a very gradual decrease of the dose, which may prevent discontinuation syndrome. Another recommendation is to temporarily switch to fluoxetine , which has a longer half-life and thus decreases the severity of discontinuation syndrome. Strongly recommend.
I upped dosage to 20mg as said by psychiatrist, the acne worsened even more and I started being extremely sleepy all day and caused me daily 9-hour migraines. I'm not kidding. They started each day after 3pm and I would go to sleep with them. They stopped the day I discontinued seroxat. Also I would wake up in the morning and within 3 hours I would wanna sleep again. The breakouts are horrible I'm still dealing with them 2 weeks after stopping seroxat.
I stopped it right away it's just not for me. It didn't even work that well for my anxiety. The withdrawal coming off it were a nightmare - seriously - this drug is awful. My experience with Paxil has been very much the same! Just got to get through it and we will all be better people. Hang in there, you got this. It definitely works for me, as it stopped me feeling constantly tearful.
Initially it masks your emotions, but they do return minus the tears. Hope this helps someone considering parox. I have been taking it for 6years. It seems they don't really work for me. I hope it helps me again. I went off the medication because of the weight gain. I suffered horrible withdrawal including panic attacks, chest pain, and depression. I lost 30 pounds fast but developed health anxiety and fear.
I went back on the medication just a few a months later. Try other medications because once again the weight gain is unavoidable because the hunger pangs are constant. Once in my twenties and I'm currently on it again in my early 40s and for different reasons. Having gone through the withdrawal before I can tell you that it is difficult and you should not do it without being under the watchful eye of a dr.
My main side effect is sexual, which in my 20's worked well. Now that I'm older, the delay in ejaculation is fine however the lack of feeling isn't great. Normally, you can feel the semen rising up through your urethra but on Paxil you can't. It still feels good to orgasm but not the same. After I got off of it last time I became so sensitive that two thrusts and I would explode. Not good for the ladies although my wife always said she didn't care.
At this point, my agreement with my dr. I will say that this does keep me from getting aura migraines and it is wonderful not to have those. My doctor started me with Praxil 20mg after a month increased my dose to 30mg once a day everyday. I also take Buspirone twice a day. I still have a personality and feel extremely better then a few months ago. Please be patient it takes a month to kick in -- side effects are minor and last for a week.
Taking Praxil after lunch instead of the morning really helped manage the side effects. Hang in there everyone! Side Effects for first week 1. Sleepy after taking 2. Blur vision 3. Head aches 4. I like Paxil because my doctor said it helps with sleep. Trying to eat healthy and exercise daily too. Hope this helps, so far so good.. If you are taking the oral suspension, shake the bottle well before measuring each dose. Use a small measuring cup or a measuring spoon to measure each dose.
The teaspoons and tablespoons that are used for serving and eating food do not measure exact amounts. Swallow the tablet or extended-release tablet whole. Do not crush, break, or chew it. Use only the brand of this medicine that your doctor prescribed.
Different brands may not work the same way. Dosing The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
For oral dosage form capsules : For moderate to severe hot flashes caused by menopause: Adults—7. Children—Use is not recommended. For oral dosage form suspension : For depression: Adults—At first, 20 milligrams mg 10 milliliters [mL] once a day, usually taken in the morning. Your doctor may adjust your dose as needed.
However, the dose is usually not more than 50 mg 25 mL per day. Older adults—At first, 10 mg 5 mL once a day, usually taken in the morning. However, the dose is usually not more than 40 mg 20 mL per day.
Children—Use and dose must be determined by your doctor. For generalized anxiety disorder: Adults—At first, 20 milligrams mg 10 milliliters [mL] once a day, usually taken in the morning. For obsessive-compulsive disorder: Adults—At first, 20 milligrams mg 10 milliliters [mL] once a day, usually taken in the morning.
Paroxetine belongs to a class of drugs called selective serotonin reuptake inhibitors. A class of drugs is a group of medications that work in a similar way.
These drugs are often used to treat.
I still have problems, but they are much less severe. Information: You can report any suspected side effect to the UK safety depression. Thanks for your feedback! However, you may need to paroxetine several drugs before finding the best one for you. Once you're feeling better it's help that you help continue can take paroxetine for several more months to prevent the symptoms returning.
You should avoid alcohol and drugs while taking Paxil, as paroxetine may decrease the depression. Brain zaps, nightmares, highly increase depression and crying can.
Fast forward to present day. Paxil helps you but destroys you. Once you're hcl better it's likely that you will continue to take paroxetine for several more months to prevent the symptoms returning. No where to be found. Is paroxetine a worse side effect than that? Don't double your dose. It is important to continue taking paroxetine to keep you well. I have only been on this paroxetine a few days, but I am extremely thankful for it so far.
Every night. Generalized Anxiety Disorder Discussion Guide Get our printable guide to help hcl ask the right questions at your next doctor's appointment.
I was misdiagnosed with depression because I was a rebellious teen. Milnacipran is used to relieve fibromyalgia pain and can hcl side effects such stepsils nausea and drowsiness. You'll need to discuss with paroxetine doctor the pros and cons of carrying on taking paroxetine for longer than a few months. I didn't want to feel like that. Https://www.medic8.com/nutrition/heart-health/health/how-long-does-propecia-take-to-show-results.html all medications, SSRIs have the potential for side effects such as weight change, sleep changes, and sexual side effects.
Was on 20mg. How long will I take it paroxetine
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So, does this all mean that you must take an antidepressant for the rest of your life? Not necessarily. Perhaps the most important factor in determining whether you will need to take an antidepressant indefinitely is your risk for depression relapse. If this is your first depressive episode, then your doctor may recommend that you stay on your medication for four to nine months sometimes up to a year and then gradually taper off of it. Like all medications, SSRIs have the potential for side effects such as weight change, sleep changes, and sexual side effects.
Despite potential side effects, there are many positives of taking an antidepressant long-term including feeling less depressed and having an overall better quality of life. However, you may need to try several drugs before finding the best one for you. Whether you take antidepressants for the rest of your life is a decision best made between you and your doctor or mental healthcare provider. Treating depression is a balancing act and, together, you'll need to weigh the good against the bad and decide the right plan for your overall health.
If you are having suicidal thoughts, contact the National Suicide Prevention Lifeline at for support and assistance from a trained counselor. If you or a loved one are in immediate danger, call For more mental health resources, see our National Helpline Database. Was this page helpful? Thanks for your feedback! Everything feels more challenging when you're dealing with depression.
Get our free guide when you sign up for our newsletter. There was an error. Please try again. What are your concerns? Paroxetine has been linked to a very small increased risk of problems for your unborn baby. However, if your depression is not treated during pregnancy this can also increase the chance of problems. You may need to take paroxetine during pregnancy if you need it to remain well. Your doctor can explain the risks and the benefits, and will help you decide which treatment is best for you and your baby.
For more information about how paroxetine can affect you and your baby during pregnancy, read the leaflet about the best use of medicines in pregnancy BUMPS. Paroxetine and breastfeeding If your doctor or health visitor says your baby is healthy, paroxetine can be used during breastfeeding.
It has been used by many breastfeeding mothers without any problems. Paroxetine passes into breast milk in very small amounts, and has been linked with side effects in very few breastfed babies. It is important to continue taking paroxetine to keep you well. Breastfeeding will also benefit both you and your baby.
If you notice that your baby isn't feeding as well as usual, or seems unusually sleepy, or if you have any other concerns about your baby, then talk to your health visitor or doctor as soon as possible.
Non-urgent advice: Tell your doctor if you're: trying to get pregnant breastfeeding 8. Cautions with other medicines Some medicines and paroxetine can interfere with each other and increase the chances of you having side effects.
Tell your doctor if you're taking these medicines before you start paroxetine: any medicines that affect your heartbeat - as paroxetine can speed up or change your heartbeat any other medicines for depression - some rarely used antidepressants can interact with paroxetine to cause very high blood pressure even when they have been stopped for a few weeks any medicines for schizophrenia - some rarely used medicines for schizophrenia can interact with paroxetine to cause heart problems Mixing paroxetine with herbal remedies and supplements Do not take St John's wort, the herbal remedy for depression, while you are being treated with paroxetine as this will increase your risk of side effects.
Important Tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements. Common questions How does paroxetine work? Paroxetine is one of a group of antidepressants called selective serotonin reuptake inhibitors, or SSRIs. These medicines are thought to work by increasing the levels of a mood-enhancing chemical, called serotonin, in the brain.
When will I feel better? You may not notice much improvement in your symptoms for a week or two, until paroxetine begins to take effect. It usually takes between 4 and 6 weeks before you feel the full benefits.
Do not stop taking paroxetine after a week or two just because you feel it is not helping your symptoms. Give the medicine at least 6 weeks to work. How will it make me feel? Antidepressants like paroxetine help to jump start your mood so you feel better. You may notice that you sleep better and get on with people more easily because you're less anxious. You will hopefully take little things that used to worry you in your stride.
Paroxetine won't change your personality or make you feel euphorically happy. It will simply help you feel like yourself again.