Alpha-1 Antitrypsin
Other names: AAT; A1AT
Alpha-1 Antitrypsin is a protein, which is produced by the liver; its primary responsibility is to protect the lungs against an enzyme known as elastase, which is released by the body when an individual is injured or a part of the body becomes inflamed. Elastase is an important enzyme, which breaks down proteins; however, if it is not regulated by AAT, it can start to break down healthy lung tissue.
What is the test used for?
The AAT test is used to diagnose liver dysfunction and emphysema; the test is usually used to identify the cause of early onset liver dysfunction and emphysema and can also be used to monitor an individual’s condition if they have a family history or early symptoms of either of the conditions.
The AAT test is usually recommended for children who experience symptoms of liver dysfunction and those aged under 40 who experience symptoms of emphysema.
How is the test performed?
The AAT test is done by analysing a sample of blood; the blood is usually taken from a vein on the inside of the elbow and then collected in a syringe. Once the sample has been collected, it will be bottled, labelled and sent away for analysis at a laboratory.
What do the results mean?
The AAT test can assess the levels of AAT in the blood; however it can also determine if the AAT that is being produced is normal. Abnormal AAT may indicate both liver disease and emphysema; if the test reveals that there are one or two abnormal copies of the SERPINA1 gene, this means that either low levels of AAT, or abnormal AAT, will be produced and this can be passed onto the patient’s children.
If levels of AAT are normal but are lower than average, this may indicate that there is risk of developing emphysema; the lower the levels of AAT, the greater the risk of developing emphysema.
There are many other health conditions which may cause AAT levels to be higher than usual; this is because AAT is classified as an acute phase reactant (this means the levels will increase in response to an infection, inflammation and some forms of cancer). Pregnancy, stress and infections of the thyroid gland may also influence AAT levels.
Specific Blood Tests
- Specific Blood Tests
- Factor V Leiden Mutation and PT 20210 Mutation
- Ferritin Test
- Fibrinogen
- Fructosamine
- FSH Test
- G6PD
- Gastrin
- GGT
- Glucose test
- Growth hormone
- Haemoglobin
- Haptoglobin
- HbA1c test
- HDL Cholesterol Test
- Helicobacter Pylori test
- Heparin Anti-Xa
- Hepatitis A Virus
- Hepatitis B Virus
- Hepatitis C Virus
- Her-2/neu Testing
- Heterophil Antibody Titre
- High-Sensitivity C-Reactive Protein
- HIV Antibody Test
- HIV Resistance Testing
- HIV Viral Load
- IGF-1
- Immunoreactive Trypsin
- Insulin
- Iron test
- LDH
- LDL Cholesterol Test
- Lead Test
- LH Test
- Lipase Test
- Lipoprotein (a)
- Lithium
- Lupus Anticoagulant
- Lyme disease test
- Maternal screening
- Mercury, Urine and Blood
- Mycophenolic Acid
- Myoglobin Test
- Oestrogen
- Osmolality
- Overdose Drug Test
- Paracetamol
- Parathyroid Hormone
- Parvovirus B19
- PCV
- Pertussis
- Phenobarbital
- Phenytoin
- Phospate
- Platelet Count
- Porphyrins
- Potassium Test
- Prealbumin Test
- Procalcitonin
- Progesterone Test
- Prolactin
- Prostate-Specific Antigen
- Protein 24 Capsid Antigen
- Protein C and Protein S
- Protein Electrophoresis Immunofixation Electrophoresis
- Prothrombin Time
- PSEN1 Test
- PTH
- Reticulocyte count
- Rheumatoid factor
- Rubella test
- Salicylic Acid
- Serotonin
- Sex Hormone Binding Globulin
- Sickle Cell Test
- Sirolimus
- Smooth Muscle Antibody
- Sodium Test
- Soluble Mesothelin-Related Peptides
- Synacthen Test
- Syphilis Test
- Tacrolimus
- Tau protein
- Testosterone Test
- Theophylline & Caffeine
- Thiopurine s-methyltransferase
- Thyroglobulin (Tg)
- Thyroid peroxidase antibody (TPOAb)
- Thyroid-Stimulating Hormone
- Thyroxine
- TIBC, UIBC & Transferring
- TORCH Test
- Total Protein test
- Triiodothyronine
- Triglycerides Test
- Troponin test
- Urea test
- Uric Acid
- Valproic Acid
- Vancomycin
- Very Low Density Lipoprotein
- Vitamin B12 and Folate
- Vitamin D
- West Nile Virus
- White blood cell differential count
- Zinc Protoporphyrin
- Activated Clotting Time
- ACTH
- Albumin
- Aldosterone and Renin
- Alkaline Phosphatase Test
- Allergen-Specific IgE Antibody Test
- Alpha-1 Antitrypsin
- Alpha-Fetoprotein
- ALT
- AMA
- Ammonia
- Amylase Test
- Angiotensin Converting Enzyme
- Antinuclear Antibody
- Antithrombin
- Apolipoprotein A-I
- Apolipoprotein E Genotyping
- aPTT
- AST
- Bicarbonate
- Bilirubin
- Blood cultures
- Blood film
- Blood Gas Tests
- Blood Ketones
- Brain Natriuretic Peptide
- BRCA-1 & BRCA-2
- CA 125
- Cancer Antigen 15-3
- Cancer Antigen 19-9
- C-peptide
- Caeruloplasmin
- Calcitonin
- Calcium Test
- Carbamazepine
- Cardiac Risk Assessment
- Cardiolipin Antobodies
- Catecholamines, Plasma and Urine
- CCP
- CD4 and CD8
- CEA Test
- CF Gene Mutation Testing
- Chickenpox and Shingles Tests
- Chloride Test
- Cholesterol Test
- Chlorinesterase Test
- Chromogranin A
- Ciclosporin
- CMV
- Coagulation Factors
- Coeliac Disease Tests
- Copper
- Cortisol Test
- Creatine Kinase CK-MB Test
- Creatine Kinase Test
- Creatinine
- Creatinine Clearance
- C-Reactive Protein
- Cystatin C
- D-Dimer
- DHEAS
- Digoxin
- Direct LDL cholesterol
- eGFR - Calc. Creatinine Clearance
- Electrolytes
- Epstein-Barr Virus Antibodies
- Erythrocyte Sedimentation Rate
- Erythropoietin
- Ethanol
Blood Test Guide
- Blood Tests
- Types of blood tests
- what to expect
- What are the risks of blood tests?
- What do blood tests show?
- Specific Blood Tests