Aplastic Anaemia

What Is Aplastic Anaemia?

Aplastic anaemia is a rare and serious blood disorder in which bone marrow stops making enough new blood cells. Bone marrow––the spongy material inside bones—makes new blood cells called stem cells. Stem cells normally develop into three main types of blood cells: red blood cells, white blood cells, and platelets. Each type of blood cell has its own functions in the body.

It is normal for blood cells to die. The lifespan of red blood cells is about 120 days. White blood cells live less than 1 day. Platelets live about 6 days. As a result, bone marrow must constantly make new blood cells. The term "anaemia" is most often used to mean a condition in which a person’s number of red blood cells is too low or their red blood cells do not carry enough haemoglobin. However, in aplastic anaemia, normal production of all blood cells—red cells, white cells, and platelets—slows or stops. This is because the stem cells have been damaged. The cause of this damage is often unknown.

Effects of Aplastic Anaemia on the Body

A shortage of any one of the three main types of blood cells will have an effect on the body. In aplastic anaemia, however, the body must cope with a shortage of all three types of blood cells. Severe aplastic anaemia that is not treated promptly can be fatal.

The effect on the body of a shortage of each type of blood cell is described below:

Too few red blood cells. Red blood cells contain haemoglobin, which is an iron-rich protein that gives blood its red colour. Haemoglobin carries oxygen from the lungs to the rest of the body. Red blood cells also remove carbon dioxide (a waste product) from cells and carry it to the lungs to be exhaled. If there are not enough red blood cells, too little oxygen is carried to the body and too little carbon dioxide is carried away. People who have a low red blood cell count often feel tired because the body is not getting enough oxygen. An untreated or severely low red blood cell count can lead to many problems. The heart has to work harder to pump blood to get enough oxygen to the body’s organs and tissues. Over time, this stress on the heart can cause fast or irregular heartbeats, an enlarged heart, or even heart failure.
Too few white blood cells. White blood cells fight infection and are an important part of the body’s defense system. When the number of white blood cells in the blood is lower than normal, the body is less able to fight infections. A person may become ill more often, and the illness may be very severe or last a long time.
Too few platelets. Platelets are needed to help blood clot. If the platelet count is low, blood cannot clot normally. A person with a low platelet count may bruise or bleed easily, and the bleeding may be hard to stop.

Important General Information

Aplastic anaemia is a rare condition. In the United States, about 500–1,000 people develop this type of anaemia each year. It is two to three times more common in Asian countries.

The two main types of aplastic anaemia are acquired and hereditary. Acquired means a person develops the condition during his or her lifetime. Hereditary means a person is born with the condition. Acquired aplastic anaemia is the most common type, and it is sometimes a temporary condition. It can be triggered by exposure to:

Toxic chemicals
Chemotherapy drugs
Radiation
Virus infections

However, the cause of acquired aplastic anaemia is often not known.

Hereditary aplastic anaemia is rare. It occurs with some inherited conditions, such as Fanconi anaemia.

Severity of Aplastic Anaemia

Aplastic anaemia can begin suddenly or develop slowly. It tends to get worse over time, except when a cause can be found and removed. Its severity ranges from mild to very severe.

People with mild or moderate aplastic anaemia have low blood counts that the doctor will check often. If the blood counts do not get worse, treatment may not be needed.
People with severe aplastic anaemia have very low blood counts. The condition can become life threatening if it is not treated.
People with very severe aplastic anaemia have extremely low blood counts. This condition is life threatening. It needs emergency hospital treatment.

Although aplastic anaemia is not cancer, the treatments for it are similar to those used for some types of cancer. Treatments include blood transfusions and bone marrow transplants. Treatments also include medicines to suppress the immune system, stimulate the bone marrow, and treat infections.

Outlook

Many people with aplastic anaemia can be treated successfully if they have prompt and appropriate treatment. Some people with aplastic anaemia can be cured with a bone marrow transplant.

Other Names for Aplastic Anaemia

Bone marrow failure

What Causes Aplastic Anaemia?

Aplastic anaemia is caused by damage to stem cells in the bone marrow. Stem cells normally develop into three types of blood cells: red blood cells, white blood cells, and platelets. When stem cells are damaged, they do not grow into healthy blood cells.

In more than half of people with aplastic anaemia, the cause of the damage to stem cells is unknown. Some research suggests that stem cell damage may occur because the body’s immune system attacks its own cells by mistake.

Causes of Acquired Aplastic Anaemia

The cause of acquired aplastic anaemia has been linked to outside agents, as well as to diseases. Outside agents include toxins such as pesticides, arsenic, and benzene; radiation and chemotherapy used to treat cancer; and medicines such as chloramphenicol, an antibiotic now rarely used in the United States. Infectious diseases also can cause aplastic anaemia. Some of these diseases are hepatitis, Epstein-Barr virus, cytomegalovirus (si-to-MEG-a-lo-VI-rus), parvovirus B19, and HIV. Autoimmune diseases, such as lupus and rheumatoid arthritis (ROO-ma-toyd ar-THRI-tis), also can cause this condition.

Causes of Hereditary Aplastic Anaemia

Some inherited genetic disorders can lead to aplastic anaemia. These include Fanconi anaemia, Shwachman-Diamond syndrome, and dyskeratosis congenita.

Who Is At Risk for Aplastic Anaemia?

Aplastic anaemia is a rare condition. In the United States, about 500–1,000 people develop this type of anaemia each year. It is two to three times more common in Asian countries.

People of all ages can develop aplastic anaemia. Men and women are equally likely to have it. It is most common in adolescents and young adults as well as the elderly.

Aplastic anaemia is more likely to develop in people who:

Have been exposed to toxins, certain drugs, or radiation
Are infected with viruses, such as hepatitis and HIV
Have an inherited disorder, such as Fanconi anaemia, or an autoimmune disease

What Are the Signs and Symptoms of Aplastic Anaemia?

Most of the signs and symptoms of aplastic anaemia are caused by low numbers of each of the three main types of blood cells—red blood cells, white blood cells, and platelets. Other signs and symptoms are not linked to a shortage of any particular blood cell type.

Too Few Red Blood Cells

The most common symptom of a low red blood cell count is low energy and feeling tired. This is caused by lack of enough haemoglobin, an iron-rich protein contained in red blood cells that carries oxygen to the body. A lack of enough oxygen in the blood can cause people to feel short of breath and dizzy, especially when standing up. Since the heart must work harder to circulate the reduced amount of oxygen, symptoms also can include a rapid or irregular heartbeat or an extra or unusual sound heard during the heartbeat (heart murmur).

The haemoglobin in red blood cells gives blood its red colour. Lack of haemoglobin due to a low red blood cell count can lead to pale skin, gums, and nail beds.

Too Few White Blood Cells

White blood cells help fight infections. Signs and symptoms of a low white blood cell count are fevers, frequent infections which can be severe, and flu-like illnesses that linger.

Too Few Platelets

People who do not have enough platelets tend to bruise and bleed easily, and the bleeding may be hard to stop. Common types of bleeding related to too few platelets include nosebleeds, bleeding gums, pinpoint red bleeding spots on the skin, and blood in the stool. Women also may have heavy menstrual bleeding.

Other Signs and Symptoms

Aplastic anaemia can cause other signs and symptoms as well. Some occur in the area of the head. These signs and symptoms include headache, tender sinuses, and white patches in the mouth (oral thrush). Other signs and symptoms are nausea and rash. A person with aplastic anaemia also may have an enlarged spleen or liver.

Paroxysmal Nocturnal Haemoglobinuria

About one-third of people with aplastic anaemia have a condition called paroxysmal (par-ok-SIZ-mal) nocturnal haemoglobinuria (PNH). This is a disorder of the red blood cells. Most people with PNH don’t have any signs or symptoms. If they do occur, they may include:

A low number of red blood cells, which can lead to shortness of breath
Swelling or pain in the abdomen or swelling in the legs caused by blood clots
Blood in the urine
Headache
Jaundice (yellowish colour of the eyes or skin)

Some people have PNH first and then develop aplastic anaemia. But this process can also happen in reverse. People may have aplastic anaemia first and then develop PNH later.

How Is Aplastic Anaemia Diagnosed?

Aplastic anaemia is diagnosed using a medical and family history, a physical exam, and tests to discover the type and cause of anaemia. Your doctor can use these methods to find out how severe the anaemia is and to decide the appropriate treatment.

Specialists Involved

A person with suspected aplastic anaemia may be referred to a haematologist (an expert in treating blood conditions).

Medical and Family History

During a medical history, your doctor may ask detailed questions about many kinds of symptoms. He or she may ask if you have ever had problems with anaemia, had an illness or condition that could cause anaemia, or been exposed to drugs, chemicals, or radiation. The doctor will ask about medicines you are taking to see if they might be a cause of the anaemia. The doctor will also ask if your family members have ever had any kind of anaemia.

Physical Exam

Your doctor will do a physical exam to see how severe the anaemia is and to check for its possible causes. This exam may include:

Checking for pale or yellowish skin
Listening to the heart for rapid or irregular heartbeats
Listening to the lungs for rapid or uneven breathing
Feeling the abdomen to check the size of the liver and spleen and checking for swelling in the legs
Checking for signs of bleeding

Diagnostic Tests and Procedures

Several tests of the blood and bone marrow may be used to diagnose aplastic anaemia. The reasons for testing are to:

Confirm a diagnosis of aplastic anaemia and look for its cause
Rule out blood cancers that can cause bone marrow failure
Determine the severity of the aplastic anaemia
Check for the presence of paroxysmal nocturnal haemoglobinuria

Complete Blood Count

Usually, the first test used to diagnose anaemia is a complete blood count (CBC). The CBC tells a number of things about a person’s blood, including:

The haemoglobin level. Haemoglobin is the iron-rich protein in red blood cells that carries oxygen through the body. The normal range of haemoglobin levels for the general population is 11–15 g/dL. A low haemoglobin level means a person has anaemia.
The haematocrit (hee-MAT-oh-crit) level. The haematocrit level measures how much of the blood is made up of red blood cells. The normal range for haematocrit levels for the general population is 32–43 percent. A low haematocrit level is another sign of anaemia.

The normal range of these levels may be lower in certain racial and ethnic populations. Your doctor can explain your individual test results.

The CBC also checks:

The number of red blood cells. Too few red blood cells means a person has anaemia. A low number of red blood cells is usually seen with either a low haemoglobin or a low haematocrit level, or both.
The number of white blood cells. White blood cells are involved in fighting infection.
The number of platelets in the blood. Platelets are small cell fragments that are involved in blood clotting.
Red blood cell size. The mean cell volume measures the average size (volume) of red blood cells.

Reticulocyte Count

This test measures the number of new red blood cells in the blood. It helps doctors find out whether bone marrow is producing red blood cells at the proper rate. A lower than average level can mean that the bone marrow is not making enough red blood cells. The reticulocyte (re-TIK-u-lo-site) level is low in people with aplastic anaemia.

Bone Marrow Tests

This test looks at the bone marrow to see if it is healthy and if it is making enough blood cells. A small amount of bone marrow may be removed and examined. Removing a small bit of liquid bone marrow is called aspiration. Removing bone marrow tissue is called biopsy.

A bone marrow aspiration may be done to find what is causing the low production of blood cells. Since blood cells are formed inside the bones, doctors use a needle to remove a small amount of liquid bone marrow. The sample is then examined under a microscope to check for abnormal cells.

A bone marrow biopsy is usually done at the same time, especially if an aspiration was not productive. A small number of bone marrow cells with a small piece of bone is removed using a needle. This test checks the number and type of cells in the bone marrow. In aplastic anaemia, the bone marrow has a lower than normal number of cells.

Other Tests

Additional tests may be used to help diagnose aplastic anaemia, including:

X ray, CT scan, or ultrasound of the abdomen to look for an enlarged spleen or lymph nodes, which could indicate blood cancer. These tests also may be used to examine the kidneys, arms, and hands, which are sometimes abnormal in young people with Fanconi anaemia.
Chest x ray to provide a picture of the heart and lungs and rule out infection.
Liver tests and viral studies to check for hepatitis and viruses.
Tests that check vitamin B12 and folate levels to rule out anaemia due to vitamin deficiency.
Blood tests for paroxysmal nocturnal haemoglobinuria and to check the immune system for antibodies.

How Is Aplastic Anaemia Treated?

Treatments for aplastic anaemia include:

Blood transfusions
Bone marrow transplants
Several medicines used to suppress the immune system, stimulate the bone marrow, and prevent and treat infections

In rare cases, no treatment is needed.

In general, treatments for aplastic anaemia can limit and prevent complications, relieve symptoms, and improve quality of life. For some, a cure may be possible. Bone marrow transplants can be a cure for those people who are eligible for a transplant. Removing a known cause of aplastic anaemia (such as exposure to a toxic chemical) also can cure the disorder. Other treatments can restore blood cell counts to levels high enough so that a person can live a normal life.

Who Needs Treatment

People with mild or moderate aplastic anaemia may not need treatment as long as the condition does not get worse. People with severe aplastic anaemia need immediate medical treatment to prevent complications from the very low levels of blood cells in their bodies. People with very severe aplastic anaemia need emergency medical care and hospitalization or the anaemia can be fatal in a short time.

Blood Transfusions

Blood transfusions are used to keep blood counts high enough in people with aplastic anaemia. Healthy blood is taken from matched donors and then given to the person with aplastic anaemia through an injection in a vein. Blood transfusions help relieve symptoms. They are not an effective long-term treatment.

Red Blood Cells

Red blood cell transfusions help relieve lack of energy, tiredness, and shortness of breath. However, if red blood cells are given often, the immune system in the body can learn to recognise these new cells, develop antibodies against them, and destroy these newly transfused cells. Also, if red blood cells are given often, the body can build up too much iron. Excess iron from transfusions can damage the heart, liver, and other organs. If this happens, treatment may be needed to remove excess iron from the body.

White Blood Cells

White blood cells are not routinely transfused because they live in the bloodstream for less than 1 day. However, they may be used for severe infections that are not being helped by antibiotics.

Platelets

Platelet transfusions reduce the risk of fatal bleeding. Several transfusions a month are often needed because platelets live only a few days. However, in time, the immune system will learn to recognise and destroy newly transfused platelets by making antibodies, just as it does with red blood cells.

Bone Marrow Transplantation

A bone marrow transplant replaces damaged stem cells in bone marrow with healthy stem cells from a donor’s bone marrow. It is the best treatment choice for eligible people because it usually cures aplastic anaemia.

A bone marrow transplant works best in children and young adults with severe aplastic anaemia who are in good health and who have matched donors. Older people are less able to tolerate the treatments needed to prepare the body for the transplant. They also are more likely to have complications after the transplant. There are age limits for who can receive a bone marrow transplant, but they vary among hospitals.

Finding a Donor

For best results, the donor’s bone marrow must be a close match with the bone marrow of the person with aplastic anaemia. A matched donor is found by means of a blood test that looks at proteins on the surface of body cells. These proteins are called human leukocyte antigens (HLA). The donor and the person with aplastic anaemia are both tested. The HLA antigens on their cells are compared.

Bone marrow transplants work best if the donated marrow is an exact match and comes from a family member, such as a brother or sister. A person receiving bone marrow that is an exact match usually has fewer complications. Only about 20–35 percent of people with severe aplastic anaemia have an HLA-matched family member to donate bone marrow.

If no matching family member is found, the search for bone marrow widens. Doctors will look for:

Donors who are HLA matches but are not family members
Family members who are not exact HLA matches
Unrelated donors who are not exact HLA matches
Umbilical cord blood that is an HLA match

A person who is going to have a bone marrow transplant should not receive blood transfusions from close family members before the transplant. When a person receives blood transfusions, their bodies can develop antibodies against the donated blood. If a person develops antibodies against the blood of a close family member, the person would not be able to receive a bone marrow transplant from that family member.

Receiving the Transplant

Bone marrow transplants are done in special units in hospitals to try to protect the person with aplastic anaemia from any infections. Before the transplant, the person receives high doses of chemotherapy, radiation therapy, or both. These treatments destroy the abnormal bone marrow that is not producing blood cells.

A sample of bone marrow is taken from the donor and is given to the recipient through a vein. The donated bone marrow stem cells travel to the recipient’s bone marrow and start to make healthy blood cells. If the transplant is successful, the new stem cells multiply and begin making new, healthy blood cells within 3 to 4 weeks.

Possible Complications

After a bone marrow transplant, the recipient is in the hospital for weeks or months. During this time, he or she is isolated and closely watched for infections and other complications. Complications are most likely to occur in the first 100 days after a transplant. Complications include rejection of the graft and what is called graft-versus-host disease (GVHD).

Graft rejection. Sometimes, the recipient’s immune system destroys the new bone marrow cells. This occurs in 5 to 10 percent of recipients, and it is more likely to happen in people who have had several bone marrow transplants.

GVHD. GVHD happens when the new immune system cells, created by the donated bone marrow, attack the recipient’s body. Signs and symptoms are skin inflammation, diarrhoea, and liver disease. GVHD can occur soon after transplant, or it can develop slowly and can last for months or years. GVHD most often happens in older people and those who receive unmatched transplants.

To help prevent GVHD, donor marrow is sometimes treated or people may be given medicines that suppress the immune system after the transplant. Those who develop mild but acute GVHD are treated with medicines such as steroids.

Medicines To Stimulate Bone Marrow

Manmade versions of substances that occur naturally in the body are used to stimulate the bone marrow to produce more blood cells. Bone marrow that can produce more blood cells can help a person with aplastic anaemia avoid blood transfusions. An increased number of white cells can help protect a person from infection. Examples of bone marrow stimulation medicines used to treat aplastic anaemia are:

Erythropoietin (e-RITH-ro-PO-e-tin)
Colony-stimulating factors

Medicines To Suppress the Immune System

Since research suggests that aplastic anaemia may occur because the body’s immune system attacks its own cells by mistake, certain medicines may be used to suppress the body’s immune system. They allow the bone marrow to start making blood cells again, and they help avoid the need for blood transfusions. Medicines that suppress the immune system do not cure aplastic anaemia, but they can relieve its symptoms and reduce its complications.

These medicines are often used for people who are not good candidates for a bone marrow transplant or who are waiting for a bone marrow transplant.

There are three medicines—often given together—that will suppress the body’s immune system:

Antithymocyte globulin (ATG)
Cyclosporine
Methylprednisolone (a corticosteroid)

If this treatment is successful, it may take a few months to notice the effects of these medicines. Most often, as blood counts rise, symptoms lessen. Blood counts in people who respond well to these drugs do not usually reach normal levels, but they are often high enough to allow people to take part in their normal activities. People with aplastic anaemia may need to take the medicines indefinitely to keep their blood counts high enough to resume normal daily life.

Medicines that suppress the immune system can have side effects. They also may increase the risk of developing leukemia (loo-KE-me-a) or myelodysplasia (MI-e-lo-dis-PLA-ze-a; MDS). Leukemia is a type of cancer in which the number of white blood cells increases. MDS is a condition in which the bone marrow produces too many defective blood cells.

Antibiotics

Antibiotics and antivirals are given to people with aplastic anaemia to prevent and treat infections.

Living With Aplastic Anaemia

Many people with aplastic anaemia can be treated successfully and some can be cured. Most people are able to resume their normal activities after treatment. If you are being treated for aplastic anaemia, it may take a long time to get a good response from your treatment. You may need repeated treatments, or you may need to try several treatments before finding one that works.

Lifelong followup is needed to make sure the disorder doesn’t return, as well as to check for possible complications.

Ongoing Health Care Needs

Treatment for aplastic anaemia can result in side effects or complications. Your doctor can talk with you about how to cope with symptoms of aplastic anaemia, side effects of treatment, and complications from treatment.

Recommended Physical Activity

Your doctor might discuss what type and amount of physical exercise may be helpful. For example, you may need to avoid activities that cause chest pain or shortness of breath. You may want to stay away from activities that could result in injuries and bleeding, such as contact sports.

Protection From Infection

Your doctor also might discuss ways to reduce your chance of getting an infection. These ways include staying away from people who are ill, avoiding crowds, and avoiding certain kinds of foods that could expose you to bacteria (for example, uncooked food can be a source of bacteria). You may be advised to wash your hands thoroughly several times throughout the day and to care for your teeth and gums to reduce the risk of infection in your mouth or throat.

It is important to know the signs of infection, such as a fever. Call your doctor at the first sign of an infection.

Key Points

Aplastic anaemia is a rare and serious blood disorder that happens when bone marrow stops making enough new blood cells.
Blood contains three types of cells: red blood cells, white blood cells, and platelets.
- The haemoglobin in red blood cells carries oxygen through your bloodstream to your body’s tissues and organs and removes carbon dioxide (a waste product).
- White blood cells fight infection.
- Platelets help the blood to clot.
In aplastic anaemia, the numbers of all three blood cell types are too low.
The two main types of aplastic anaemia are acquired and hereditary. Acquired aplastic anaemia can be caused by exposure to toxic chemicals, radiation, certain medicines, or viruses. Hereditary aplastic anaemia occurs with certain inherited conditions, such as Fanconi anaemia.
Common signs and symptoms of aplastic anaemia are:
- Low energy, tiredness, and weakness
- Bleeding that is hard to control
- Frequent fever or infections that linger
Aplastic anaemia is diagnosed using medical and family history, a physical exam, and a number of tests and procedures.
- A complete blood count measures the number of all types of blood cells.
- Bone marrow tests give important information about the number and quality of bone marrow cells.
- Other tests may include studies of the abdomen, chest, and liver.
Treatments for aplastic anaemia include blood transfusions, bone marrow transplant, and medicines.
- Blood transfusions help with the immediate problems of bone marrow failure but are not a permanent treatment.
- Bone marrow transplant can cure aplastic anaemia in some people.
- A number of medicines are used to treat aplastic anaemia. They can suppress the immune system, stimulate the bone marrow, and treat infections.
With appropriate treatment, many people with aplastic anaemia can be treated successfully and can live normal lives. Some people with aplastic anaemia can be cured with a bone marrow transplant.